Objective Colorectal cancer is primarily treated with surgery. Major surgery and older age are risk factors associated with postoperative decline in cognitive function. In clinical research, a wide ...

Objectives The increasing complexity and scale of medical education in the UK demands increasing numbers of medical educators. A small proportion of educators are qualified doctors, but did not reach ...

Objective To synthesise qualitative studies that explore prescribers’ perceived barriers and enablers to minimising potentially inappropriate medications (PIMs) chronically prescribed in adults.

Introduction Early warning scores (EWSs) are used extensively to identify patients at risk of deterioration in hospital. Previous systematic reviews suggest that studies which develop EWSs suffer ...

Objectives To investigate mortality and its causes in adults over the age of 20 years with intellectual disability (ID). Design, setting and participants Retrospective population-based standardised ...

Original research: Cost-effectiveness of percutaneous mitral repair for patients with severe secondary mitral regurgitation: an updated evaluation using a modelling approach based on COAPT final data ...

1 Centre of Expertise on Quality and Safety, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands Objective Although the guiding principle of clinical governance ...

Setting England between 2001 and 2010. Participants All people whose death was registered in England between 2001 and 2010 and whose certificate contained a sepsis-associated International ...

Objectives To evaluate the efficacy and safety of intra-articular (IA) bupivacaine administered for pain relief after joint arthroplasty. Design Meta-analysis. Methods A systematic review was ...

Introduction Inspiratory muscle training (IMT) has been applied during pulmonary rehabilitation in patients with chronic obstructive pulmonary disease (COPD). However, it remains unclear if the ...

1 University of Bristol, Centre for Academic Primary Care, School of Social and Community Medicine, Bristol, UK 2 University of Sheffield, Medical Care Research Unit, School of Health and Related ...

Objectives Multimorbidity—the co-occurrence of at least two chronic diseases in an individual—is an important public health challenge in ageing societies. The vast majority of multimorbidity research ...