Peripheral sensory nerves innervating the skin and internal organs convey information about the external and internal environment. Individual neurons display sensitivities to one or more modalities ...

Please provide your email address to receive an email when new articles are posted on . WASHINGTON — A TRPM8 agonist demonstrated early onset of action in the treatment of signs and symptoms of dry ...

Recent studies have indicated that the protein known as TRPM8 plays an important role in prostate cancer: high levels of TRPM8 have been found in prostate carcinoma compared to normal prostate ...

The transient receptor potential melastatin 8 (TRPM8) ion channel is the primary detector of environmental cold and an important target for treating pathological cold hypersensitivity. Here, we ...

Lamina I projection neurons that respond selectively to skin cooling receive monosynaptic input from Trpm8-expressing primary afferents and innervate brain regions involved in perception of cold and ...

A three-dimensional reconstruction of TRPM8 embedded in a cell membrane. Four TRPM8 proteins are assembled as a functional ion channel. The TRPM8 proteins are shown in light blue and gray, and the ...

Scientists have revealed how the body’s microscopic cold sensor, TRPM8, detects both chilly temperatures and the cooling effect of menthol. The discovery finally shows how the sensation of “cool” ...

The first determination of the atomic structure of Transient Receptor Potential Melastatin 8 (TRPM8), a molecular sensor in nerve ends that detects cold temperatures as well as menthol and other ...

Scientists at the USC Dornsife College of Letters, Arts and Sciences have found that blocking or removing a protein called TRPM8 in mice prevented them from experiencing migraine-like symptoms. In ...

TRPM8 is a member of the transient receptor potential channel (TRP) family. TRPM8 is known to be a thermosensitive channel, activated by cold temperatures and ligands such as menthol, Eucalyptol and ...