In order to design a ribozyme to cleave TNF-α mRNA, we first had to predict the secondary structure of mTNF-α mRNA to identify an accessible target site for the ribozyme. This was carried out ...

For example, just one anti-TNF iteration from corporate giant Johnson and Johnson, called Remicade, accounted for nearly 10 percent of that company’s entire global revenue in 2013. The drugs are ...

New findings on TB could change how we treat inflammatory disorders. Rockefeller University. Journal Nature DOI 10.1038/s41586-024-07866-3 ...

In these two patients, the TNF gene failed to function, preventing the respiratory burst from occurring, and thus the creation of ROS molecules. As a result, the patients' alveolar macrophages ...

Duke researchers now have discovered that a gene called uhrf1 acts like a kind of molecular handbrake on TNF. In the absence of uhrf1, TNF rolls out a series of pro-inflammatory and immune signals ...

A specific variant of the TNF-alpha gene predicts faster progression of rheumatoid arthritis. (American College of Rheumatology 2004 meeting.) ...

Cite this: Novel TNF-alpha Vector and Gene May Enhance Chemoradiation for Esophageal Cancer - Medscape - Jan 25, 2010. Authors and Disclosures. Authors and Disclosures Journalist ...

According to Exicure, AST-005 can penetrate the skin when applied topically and knockout the TNF gene of interest due to the unique ability of SNA constructs.

Xentria’s bid to find a new use for TNF inhibitors has landed it with $45 million in the bank. Building on evidence that Remicade improves outcomes in a lung disease, Xentria has persuaded ...

Children and adolescents with Crohn’s disease who received anti-tumor necrosis factor-alpha therapy showed rapid improvement in trabecular bone mineral density and cortical structure besides ...

The two were the only members of their extended family with a mutation in the TNF gene, which encodes for proteins linked to the regulation of a variety of biological processes. Short for "tumor ...