Misfolded, prion-like proteins drive the progression of tauopathies, a group of neurodegenerative diseases—including Alzheimer's disease—characterized by the abnormal accumulation of misfolded ...

The model enables the study of the fundamental interactions that underlie neurodegenerative disease. Researchers from ...

A new study has uncovered a molecular mechanism in the prion protein that may explain why nerve cells degenerate in prion diseases such as Creutzfeldt-Jakob disease (CJD). The findings, which appear ...

When prion proteins mutate, they trigger mad cow and Creutzfeldt-Jakob disease. Although they are found in virtually every organism, the function of these proteins remained unclear. Researchers ...

The patient was unknowingly infected with an abnormal protein that causes a rare, fatal neurological disease with no treatment.

A team headed by Professor Jörg Tatzelt, head of the Department of Biochemistry of Neurodegenerative Diseases at Ruhr University Bochum, Germany, showed that misfolded prion proteins can inactivate ...

A study from Bochum describes a mammal-specific domain of the prion protein and offers new approaches for research into neurodegenerative diseases. At first, they cause memory deficits and ...

The findings are published in the journal BMC Cancer. In the study, the team discovered that the prion protein plays a key ...

Protein aggregation is typical of neurodegenerative diseases such as Alzheimer's, Parkinson's and prion diseases such as Creutzfeld-Jakob disease. A research team headed by Professor Jörg Tatzelt ...

In the field of COVID-19 research, attention has turned to a critical aspect: the prion region on the surface spike proteins of the virus and its implications, especially in the context of mRNA ...

Collaborating with a genome-editing lab, they have developed a tool that can turn off expression of the prion protein in a mouse’s brain and that might work for other disease-related proteins ...