Bioengineers at the University of California, San Diego have proven that when it comes to guiding stem cells into a specific cell type, the stiffness of the extracellular matrix used to culture them ...

Schematic diagram depicting the mechanism of the rigid matrix regulating cell glycolysis in degenerated NPCs. In degenerated NP tissue, MRTF-A was activated by increased matrix stiffness and ...

Theoretical development of a dynamic stiffness matrix (DSM) based direct damping matrix identification method is revisited in this paper. This method was proposed to identify both the mechanism and ...

Using a unique stiffness-changing hydrogel system, investigators at the University of California San Diego (UCSD) have uncovered new insights into how the stiffening of breast tissue plays a role in ...

Similarly to how a picked lock gives away that someone has broken into a building, the stiffening of a structure surrounding cells in the human body can indicate that cancer is invading other tissue.

Cardiovascular disease is the leading cause of death in humans. Worldwide, as the population ages, the burden of treating heart failure is increasing; opportunities for heart transplantation cannot ...

For in vitro cellular assays, the extracellular matrix—the material between cells—often is overlooked, but changes within this microenvironment affect cells’ proliferation and differentiation and, ...

Bioengineers have demonstrated that the stiffness of the extracellular matrix used to culture stem cells really does matter. The research team also found that a protein binding the stem cell to the ...