The San Francisco 49ers have had terrible injury luck this season, which ultimately led to the end of their playoff hopes. Just a few months ago, they were in the overtime of a Super Bowl, but life ...

The San Francisco 49ers have had to deal with multiple running back injuries this season and another went down in Week 18 ...

The San Francisco 49ers list of players on injured lists ballooned to 16 ... wide receiver Brandon Aiyuk and running back ...

San Francisco 49ers running back Jordan Mason. / Mark Konezny-Imagn Images The San Francisco 49ers lost their top two running backs in Week 13, as Christian McCaffrey was placed on injured reserve ...

The San Francisco 49ers have been bitten badly by the injury ... which entered play on Sunday with running backs Christian McCaffrey, Jordan Mason and Elijah Mitchell on IR. Things only worsened ...

"After losing RBs Christian McCaffrey, Jordan Mason, and Elijah Mitchell to season-ending injuries, it now looks as if the 49ers will be without RB Isaac Guerendo for Sunday's game vs. Miami.

On Sunday, the San Francisco 49ers traveled to State Farm Stadium to take on the Arizona Cardinals, looking for only their seventh win of the season.

After placing RBs Jordan Mason and Christian McCaffrey on the IR, the 49ers are now promoting RB Patrick Taylor Jr. to the active roster. Considering that there’s only 5 games left in the season ...

Guerendo has been diagnosed with MCL and ankle sprains in his left leg following an MRI on Monday, but he didn't damage the ACL in his left knee during Sunday's loss at Arizona, Matt Barrows of The ...

Guerendo has risen to the top of a 49ers depth chart at the position that has been decimated by injury this season. Christian McCaffrey, Jordan Mason and Elijah Mitchell all sustained season ...

San Francisco 49ers running back Isaac Guerendo is set to return from foot and hamstring injuries and play Monday vs. the ...