The San Francisco 49ers have had to deal with multiple running back injuries this season and another went down in Week 18 ...

San Francisco 49ers RB Isaac Guerendo was carted off the field in Week 18's matchup against the Arizona Cardinals. He has ...

Rookie running back Isaac Guerendo was carted off the field early in the 49ers’ season finale in Arizona against the ...

RB Jordan Mason also suffered an injury in that game ... Taylor has played in eight games with the 49ers this year and he had an entire offseason to get familiar with their offense.

San Francisco 49ers running back Jordan Mason. / Mark Konezny-Imagn Images The San Francisco 49ers lost their top two running backs in Week 13, as Christian McCaffrey was placed on injured reserve ...

The San Francisco 49ers list of players on injured lists ballooned to 16 ... wide receiver Brandon Aiyuk and running back ...

"After losing RBs Christian McCaffrey, Jordan Mason, and Elijah Mitchell to season-ending injuries, it now looks as if the 49ers will be without RB Isaac Guerendo for Sunday's game vs. Miami.

The San Francisco 49ers have been bitten badly by the injury ... which entered play on Sunday with running backs Christian McCaffrey, Jordan Mason and Elijah Mitchell on IR. Things only worsened ...

As the first quarter wound down in his second NFL game, San Francisco 49ers running back Isaac ... time was undoubtedly on Guerendo's side. With Jordan Mason handling the bulk of the carries ...

The San Francisco 49ers running back Isaac Guerendo is dealing with a hamstring injury and is unlikely to play Sunday against ...

San Francisco 49ers running back Isaac Guerendo is set to return from foot and hamstring injuries and play Monday vs. the ...

Guerendo has risen to the top of a 49ers depth chart at the position that has been decimated by injury this season. Christian McCaffrey, Jordan Mason and Elijah Mitchell all sustained season ...