The 49ers will not be able to win the NFC West on Thursday night, but they can remain alive in the race for another week. The Los Angeles Rams make their annual trek to Levi's Stadium for a late-season game that finds both teams battling for their postseason lives.

San Francisco 49ers running back Isaac Guerendo is expected to play in Thursday's pivotal game against the LA Rams, according to multiple NFL insiders.

“49ers rookie RB Isaac Guerendo plans to play Thursday night vs. the Rams despite his sprained foot that has left him being listed as questionable, per sources. Guerendo insists he ‘feels good,'” Adam Schefter of ESPN reported in a post shared on X, formerly Twitter.