San Francisco 49ers running back Isaac Guerendo was carted off the field in the first quarter against the Arizona Cardinals.

Rookie running back Isaac Guerendo was carted off the field early in the 49ers’ season finale in Arizona against the Cardinals with a leg injury. On the fourth snap of the game, his second consecutive ...

The San Francisco 49ers entered Sunday's season finale against the Arizona Cardinals with a depleted roster. Quarterback Josh Dobbs took the reins in place ...

Guerendo won't return to Sunday's game at Arizona due to knee and ankle injuries. Guerendo had his left leg twisted under him on his second carry of the game, and his teammates quickly motioned to the ...

The 49ers came out firing on all cylinders in the first half of their loss to the Detroit Lions on Monday, but couldn’t ...

That was until Isaac Guerendo showed up. The rookie fourth-round pick in 2024 stepped into action on Sunday in Week 14, dominating the Bears to the tune of 128 total yards and two touchdowns.

The San Francisco 49ers got a great performance out of rookie running back Isaac Guerendo in his first career NFL start in Week 14 against the Chicago Bears. However, the fourth-round rookie ...

Entering a do-or-die matchup vs. the Chicago Bears this Sunday, the San Francisco 49ers are banking on rookie running Isaac Guerendo to fill the shoes left by reigning Offensive Player of the Year ...

Guerendo (foot) is listed as active Thursday against the Rams, Lindsey Pallares of the 49ers' official site reports. Guerendo came out of this past Sunday's win versus the Bears with a sprained ...

San Francisco 49ers rookie running back Isaac Guerendo sustained a foot injury and was questionable to return in Sunday's matchup with the Chicago Bears. More News: Chargers Make Game-Time ...

The latest injury update for San Francisco 49ers running back Isaac Guerendo in Week 15 against the Los Angeles Rams. San Francisco 49ers running back Isaac Guerendo. / Bob Kupbens-Imagn Images ...

Isaac Guerendo will get his first opportunity as ... This season, the Bears have been one of the better teams against the run. PFF has them ranked as the 10th-best run defense in the league.