The San Francisco 49ers got a great performance out of rookie running back Isaac Guerendo in his first career NFL start in Week 14 against the Chicago Bears. However, the fourth-round rookie ...

San Francisco 49ers running back Isaac Guerendo plans to play Thursday night against the Los Angeles Rams despite his sprained foot, sources told ESPN's Adam Schefter. Guerendo, who is listed as ...

SANTA CLARA, Calif. -- As the first quarter wound down in his second NFL game, San Francisco 49ers running back Isaac Guerendo trotted on to the field, stepped into the huddle and listened ...

With both McCaffrey and Jordan Mason on injured reserve as the 49ers head down the stretch, they turned to rookie Isaac ...

Guerendo (foot) was listed as a non-participant on Monday's estimated injury report, Nick Wagoner of ESPN.com reports. Guerendo's first career start Sunday against the Bears was fruitful until he ...