Getting hurt the Sunday before a Thursday night game gave San Francisco 49ers fans plenty of reason to be skeptical about ...

The 49ers host the Rams on Thursday Night Football. They’ve been losing running backs left and right, and now we’re awaiting ...

Isaac Guerendo was initially uncertain for Thursday night, but the rookie looks like he might give it a go. Here's the latest ...

The San Francisco 49ers have been decimated by injuries all year, specifically at the running back position. Christian ...

PM ET game airing live on Amazon Prime Video, bookmakers have posted player props for Isaac Guerendo. NFC West rivals play in ...

Most starters were on the sideline late in Week 14's lopsided win, while only one D-lineman played over 30 snaps.

The San Francisco 49ers running back spot has been a position of focus for fantasy football players throughout the season, ...

The 49ers are playing on "Thursday Night Football" against the Rams. Will running back Isaac Guerendo be ready to play after ...

Running back Isaac Guerendo is officially active for the the 49ers' pivotal "Thursday Night Football" game against the Los Angeles Rams despite dealing with a foot injury on a short week.

According to ESPN's Adam Schefter, San Francisco 49ers rookie running back Isaac Guerendo is expected to suit up for Thursday ...

It's the fantasy football playoffs, so you know it's no time to mess around. And what we've got with Isaac Guerendo is some ...

“49ers rookie RB Isaac Guerendo plans to play Thursday night vs. the Rams despite his sprained foot that has left him being ...