TRP channels are tetramers ... are consistent with an alternative ion permeation pathway in the S1–S4 region in TRPM3. However, it cannot be excluded that this mutation has an allosteric ...

For this type of ion channel, the ion pathway lies in a pore domain consisting of two transmembrane helices surrounding the so-called selectivity filter — a unique structural and chemical ...

In rats and humans alike, blocking the ion channel pore of the NMDA receptor ... nicotinic agonists-induced activation of cholinergic pathways have been shown to elicit antinociceptive effects.

Pore-forming proteins in living cells, termed ion channels, are embedded in the outer membrane of almost all cell types and ...

Researchers have uncovered a brain pathway that shuts down seizures. They found that an acid-activated ion channel in the brain reacts to a drop in pH (increased acid) in a way that shuts down ...

"TRPML2 is the first ion channel found in intracellular membranes ... as a means of optimizing the function of specific transport pathways in macrophages. "In the case of an acute infection ...

Researchers have discovered how an ion channel in the brain's neurons has a kind of 'molecular memory', which contributes to the formation and preservation of lifelong memories.

has been working to understand which ion channels are involved in dopamine release regulation. A neurotransmitter, dopamine is often portrayed as the “chemical of pleasure” due to its role in reward ...

Two studies help pave the way for a "shortcut" model-free approach to studying activation of "polymodal" ion channels -- channels that open in response to multiple stimuli. Two studies in The ...

She used the calcium-conducting channelrhodopsin XXM 2.0 and the light-activated anion channel GtACR1 to investigate the ...