San Francisco 49ers rookie running back Isaac Guerendo's 15-yard rushing score gives the 49ers their first touchdown of their "Sunday Night Football" road game against the Buffalo Bills in Week 13 ...

San Francisco 49ers running back Isaac Guerendo's second touchdown of day gets 49ers to 30-point mark vs. Chicago Bears. Watch the highlights from Super Bowl LIX between the Kansas City Chiefs and ...

President of football operations/general manager John Lynch and head coach Kyle Shanahan detailed coordinator coaching changes, takeaways from the 2024 season and potential offseason player ...

The San Francisco 49ers should have the most talented running back room in the NFL entering the 2025 season. That group, while very good, may also be their downfall.

San Francisco 49ers rookies Renardo Green, Isaac Guerendo, Malik Mustapha, and Jacob Cowing sent in advice for NFL prospects ...

San Francisco 49ers running back Isaac Guerendo joined the 49ers "You've Got Mail" podcast presented by Delta Dental to discuss his journey to the pros, the early contributions of the rookie class ...

San Francisco 49ers running backs Christian McCaffrey and Isaac Guerendo had good news on their late-season injuries, and both appear to be on track to be ready for the start of the 2025 season.

NFL Scouting Combine has arrived, and Cam Skattebo will have a chance to significantly improve his draft stock over the next ...

Guerendo, Warren can provide RB help off waivers FFHH makes cases for Jaylen Warren, Isaac Guerendo, and Tyjae Spears as the top running backs to add from waivers ahead of Week 9 action. 10:39 Now ...