The targeting of somatic hypermutation (SHM) occurs at two distinct levels. 'Global' targeting refers to the fact that rearranged immunoglobulin variable regions are the primary substrate for SHM. By ...
Activation-induced cytidine deaminase (AID) is essential for class-switch recombination (CSR) and somatic hypermutation (SHM). Mutants with changes in the C-terminal region of AID retain SHM but lose ...
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