The Cyclones at one point shot 1-for-12, while Ole Miss rattled off a 20-2 run to take the lead. Sean Pedulla sparked the scoring surge with a 3-pointer, and Matthew Murrell capped the seven-minute stretch with an and-1 to give the Rebels a 28-17 lead with 7:22 left in the first half. They hardly looked back from there.

BOTTOM LINE: No. 15 Iowa State and Ole Miss square off in the NCAA Tournament second round. The Cyclones' record in Big 12 play is 15-8, and their record is 10-1 in non-conference play. Iowa State is 22-3 in games decided by 10 points or more.

Pregame analysis and predictions of the Ole Miss Rebels vs. Iowa State Cyclones NCAAM game to be played on March 23, 2025 on ESPN.