Rookie Isaac Guerendo battled injuries himself after taking the lead role in the backfield, and was carted off during the ...

The San Francisco 49ers have had to deal with multiple running back injuries this season and another went down in Week 18 ...

Guerendo has been diagnosed with MCL and ankle sprains in his left leg following an MRI on Monday, but he didn't damage the ACL in his left knee during Sunday's loss at Arizona, Matt Barrows of The ...

RB Jordan Mason filled in admirably to start the year, but he was hit with a shoulder injury in Week 6 that he battled until ...

"After losing RBs Christian McCaffrey, Jordan Mason, and Elijah Mitchell to season-ending injuries, it now looks as if the 49ers will be without RB Isaac Guerendo for Sunday's game vs. Miami.

After losing RBs Christian McCaffrey, Jordan Mason and Elijah Mitchell to season-ending injuries, it now looks as if the 49ers will be without RB Isaac Guerendo for Sunday’s game vs. Miami.

Among those listed as “out” Friday by 49ers coach Kyle Shanahan were wide receiver Deebo Samuel (rib/wrist), cornerback ...

San Francisco 49ers running back Isaac Guerendo is set to return from foot and hamstring injuries and play Monday vs. the ...

Isaac Guerendo is active on Thursday night against the Rams despite his sprained foot. The 49ers also activated Dre Greenlaw ...