The 49ers injury woes continue at running back after Isaac Guerendo was carted off the field in the 1st quarter.

The San Francisco 49ers have had to deal with multiple running back injuries this season and another went down in Week 18 ...

After losing RBs Christian McCaffrey, Jordan Mason and Elijah Mitchell to season-ending injuries, it now looks as if the ...

The 49ers Faithful gladly bid adieu to 2024 and turn their attention to a new year featuring a new contract for Brock Purdy ...

RB Jordan Mason filled in admirably to start the year, but he was hit with a shoulder injury in Week 6 that he battled until ...

Among those listed as “out” Friday by 49ers coach Kyle Shanahan were wide receiver Deebo Samuel (rib/wrist), cornerback ...

Ten months after appearing in Super Bowl LVIII, the San Francisco 49ers were shockingly eliminated from the 2024 NFL playoffs ...

After losing RBs Christian McCaffrey, Jordan Mason and Elijah Mitchell to season-ending injuries, it now looks as if the 49ers will be without RB Isaac Guerendo for Sunday’s game vs. Miami.

San Francisco 49ers running back Isaac Guerendo is set to return from foot and hamstring injuries and play Monday vs. the ...

Can the Lions clinch the NFC 1-seed with a win? We continue our NFL odds series with a Lions-49ers prediction and pick.