A storm that produced a devastating tornado in the St. Louis, Missouri, area Friday afternoon has left at least five people dead and at least 10 injured, according to local authorities.

A significant severe weather outbreak is unfolding across the Midwest and Ohio Valley on Friday, placing more than 146 million individuals under alert.

A tornado outbreak swept across the Ohio Valley Friday night, leaving at least 21 dead and rescue crews frantically searching neighborhoods left in ruins for any other survivors. So far, at least 14 people have died in Kentucky,

At least five people have died and more than 5,000 buildings were damaged after a tornado tore through St Louis in Missouri. The tornado swept along a major road, tearing roofs off houses, uprooting trees and knocking down power lines on Friday evening.