The circulating bird flu has become “widespread” in Massachusetts, as officials believe the virus has killed 500 to 1,000 wild birds across the region.

Massachusetts officials announced Wednesday that bird flu is now considered to be “widespread” in the state and urged the public to avoid handling birds or other animals that are dead or appear sick.

The number of bird flu cases in Central Massachusetts is relatively low, compared to a swath of the state that runs from Greater Boston to Southeastern Massachusetts. That message was delivered Wednesday during a virtual update from state health officials on the highly pathogenic avian influenza H5N1 virus.