Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer: …
WEBTotal neoadjuvant therapy (TNT) is now recognized as the preferred standard for the treatment of locally advanced rectal cancer. 1 Using this approach, all nonsurgical interventions, including multiagent chemotherapy and concurrent chemoradiotherapy (CRT), are administered before surgical resection or the decision on nonoperative management is ...
Preoperative Treatment of Locally Advanced Rectal Cancer
WEBJun 4, 2023 · Pelvic radiation plus sensitizing chemotherapy with a fluoropyrimidine (chemoradiotherapy) before surgery is standard care for locally advanced rectal cancer in North America. Whether...
A Review of Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal ...
WEBJul 17, 2016 · Neoadjuvant chemoradiotherapy has become the standard treatment for locally advanced rectal cancer. Neoadjuvant chemoradiotherapy not only can reduce tumor size and recurrence, but also increase the tumor resection rate and anus retention rate with very slight side effect.
Neoadjuvant therapy for rectal adenocarcinoma - UpToDate
WEBMar 8, 2024 · For rectal adenocarcinomas that are larger or more invasive, neoadjuvant therapies are used to reduce tumor burden prior to pursuing surgery or other management strategies. This topic will present the various approaches to neoadjuvant therapy for rectal adenocarcinoma.
The clinical efficacy and safety of neoadjuvant chemoradiation therapy ...
WEBJun 2, 2022 · Background: Neoadjuvant chemoradiotherapy (nCRT) not only could bring tumor downsizing and downstaging but also could achieve clinical complete response (cCR) or pathological complete response (pCR). Although immunotherapy benefits MSI-H/dMMR rectal cancer patients, little response is observed in MSS/pMMR patients.
Locally Advanced Rectal Cancer Treatment in the Total Neoadjuvant …
WEBHowever, total neoadjuvant therapy (TNT) protocols (ie, preoperative chemotherapy in addition to radiotherapy) may allow better adherence and early treatment of distant micrometastases and may increase pathological complete response (pCR) rates.
Neoadjuvant Chemoradiation for Rectal Cancer: Is More Better?
WEBJun 2, 2008 · Neoadjuvant chemoradiation has become the favored adjuvant treatment for stages II and III rectal cancer. Compared to postoperative chemoradiation, this modality of treatment has been shown to be superior in terms of toxicity, local relapse, and sphincter-saving.[1]
Total Neoadjuvant Therapy (TNT) versus Standard Neoadjuvant ...
WEBJun 7, 2021 · Total neoadjuvant therapy (TNT) is a novel approach for locally advanced rectal cancer (LARC), which attempts to deliver both systemic chemotherapy and neoadjuvant chemoradiotherapy prior to surgery. However, its efficacy and safety remain controversial in randomized controlled trials (RCTs). We conducted this meta‐analysis to assess such concerns.
Neoadjuvant radiotherapy for rectal cancer management - PMC
WEBSep 7, 2019 · Neoadjuvant therapy involves a variety of options including radiotherapy, chemotherapy used alone or in combination. Neoadjuvant radiotherapy in rectal cancer has been shown to be effective in reducing tumour burden in advance of curative surgery.
Adoption of Total Neoadjuvant Therapy for Locally Advanced …
WEBCercek A, Goodman KA, Hajj C, et al. Neoadjuvant chemotherapy first, followed by chemoradiation and then surgery, in the management of locally advanced rectal cancer. J Natl Compr Canc Netw. 2014;12 (4):513-519. PubMed Google Scholar Crossref.
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